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CGRP antagonist 1

رقم الكتالوجGC31107

مضاد CGRP 1 هو مناهض لمستقبلات CGRP عالي الفعالية مع Ki و IC 50 من 35 و 57 نانومتر ، على التوالي

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CGRP antagonist 1 التركيب الكيميائي

Cas No.: 1123757-49-2

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Sample solution is provided at 25 µL, 10mM.

Description of CGRP antagonist 1

CGRP antagonist 1 is a highly potent CGRP receptor antagonist with a Ki and IC50 of 35 and 57 nM, respectively.

CGRP antagonist 1 is compound 20[1].

[1]. Stump CA, et al. The discovery of highly potent CGRP receptor antagonists. Bioorg Med Chem Lett. 2009 Jan 1;19(1):214-7.

Chemical Properties of CGRP antagonist 1

Cas No. 1123757-49-2 SDF
Canonical SMILES O=C(NC1=CC2=C(C[C@@]3(C4=CC=CN=C4NC3=O)C2)C=C1)CN5C(C6(CCOCC6)C7=C5C=CC=C7)=O
Formula C29H26N4O4 M.Wt 494.54
الذوبان Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of CGRP antagonist 1

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.0221 mL 10.1104 mL 20.2208 mL
5 mM 0.4044 mL 2.0221 mL 4.0442 mL
10 mM 0.2022 mL 1.011 mL 2.0221 mL
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In vivo Formulation Calculator (Clear solution) of CGRP antagonist 1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 16 reference(s) in Google Scholar.)

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