الصفحة الرئيسية>>Signaling Pathways>> Apoptosis>> Apoptosis Inducers>>CHM 1

CHM 1 (Synonyms: NSC 656158)

رقم الكتالوجGC17969 Copy One-Click Copy Product Info

An inhibitor of tubulin polymerization

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CHM 1 التركيب الكيميائي

Cas No.: 154554-41-3

الحجم السعر المخزون الكميّة
1mg
33٫00
متوفر
5mg
83٫00
متوفر
10mg
133٫00
متوفر
25mg
224٫00
متوفر
50mg
328٫00
متوفر
100mg
469٫00
متوفر

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مراجعات العميل

بناء على آراء العملاء.

Sample solution is provided at 25 µL, 10mM.



Description of CHM 1

Inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells.

Chemical Properties of CHM 1

Cas No. 154554-41-3 SDF
المرادفات NSC 656158
Chemical Name 6-(2-fluorophenyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one
Canonical SMILES C1OC2=C(O1)C=C3C(=C2)C(=O)C=C(N3)C4=CC=CC=C4F
Formula C16H10FNO3 M.Wt 283.25
الذوبان <7.08mg/ml in Water Storage Store at RT
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of CHM 1

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.5305 mL 17.6523 mL 35.3045 mL
5 mM 706.1 μL 3.5305 mL 7.0609 mL
10 mM 353 μL 1.7652 mL 3.5305 mL
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In vivo Formulation Calculator (Clear solution) of CHM 1

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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مراجعات

Review for CHM 1

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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