Chymase-IN-1 |
| رقم الكتالوجGC31930 |
Chymase-IN-1 هو مثبط قوي ، انتقائي ، فعال عن طريق الفم ، غير ببتيد لكيميز الخلية البدينة البشرية مع IC50 من 29 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 862090-74-2
Sample solution is provided at 25 µL, 10mM.
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Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.
Chymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM[1].
Chymase-IN-1 exhibits low oral bioavailability in rats (F=3%; oral t1/2=1.8 h)[1].
[1]. Greco MN, et al. Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50(8):1727-30.
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