الصفحة الرئيسية>>Signaling Pathways>> DNA Damage/DNA Repair>> Casein Kinase>>CK2 inhibitor 2

CK2 inhibitor 2

رقم الكتالوجGC62337

مثبط CK2 2 هو مثبط فعال وانتقائي وفعال عن طريق الفم لـ CK2 ، مع IC50 من 0.66 نانومتريُظهر مثبط CK2 2 انتقائية عالية لـ Clk2 (IC50 = 32.69 نانومتر) / CK2يُظهر مثبط CK2 2 نشاطًا مضادًا للتكاثر ومضادًا للأورام

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CK2 inhibitor 2 التركيب الكيميائي

Cas No.: 2641079-92-5

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
297٫00
متوفر
5 mg
270٫00
متوفر
10 mg
432٫00
متوفر
25 mg
855٫00
متوفر
50 mg
1305٫00
متوفر
100 mg
2025٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents

CK2 inhibitor 2 is a potent, selective and orally active inhibitor of CK2, with an IC50 of 0.66 nM. CK2 inhibitor 2 shows high selectivity for Clk2 (IC50=32.69 nM)/CK2. CK2 inhibitor 2 exhibits favorable antiproliferative and antitumor activity[1].

CK2 inhibitor 2 (compound 1c) exhibits potent antiproliferative activities against PC-3, HCT-116, MCF-7, HT-29, T24 and LO2 cells, with IC50s of 4.53 μM, 3.07 μM, 7.50 μM, 5.18 μM, 6.10 μM, and 96.68 μM, respectively[1].CK2 inhibitor 2 (5-20 μM; 24 h) induces apoptosis of HCT-116 cells in a dose-dependent manner. CK2 inhibitor 2 dose-dependently suppresses the expression of p-Akt1S129 and p-Cdc37S13 in HCT-116 cells[1].CK2 inhibitor 2 (1-500 nM) dose-dependently inhibits exogenous ALDH1A1 enzyme activity, with an IC50 of 0.10 μM[1].CK2 inhibitor 2 (5-20 μM; 24 h) inhibits the transcription and protein expression of ALDH1A1 in HCT-116 cells[1].

CK2 inhibitor 2 (60-90 mg/kg; p.o. twice a day for 4 weeks) obviously inhibits the tumor growth dose-dependently with a maximum inhibitory rate of 69% at a dose of 90 mg/kg[1].CK2 inhibitor 2 (25 mg/kg; a single p.o.) exhibits Cmax (7017.8 ng/mL), elimination half-life (t1/2=6.67 h), and CL (0.60 L/h/kg) in SD rats[1].

[1]. Wang Y, et, al. Discovery of 5-(3-Chlorophenylamino)benzo[ c][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition. J Med Chem. 2021 Apr 22;64(8):5082-5098.

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