Clioquinol (Iodochlorhydroxyquin) (Synonyms: Iodochlorohydroxyquin, NSC 3531, NSC 74938) |
| رقم الكتالوجGC32078 |
Clioquinol (Iodochlorhydroxyquin) (Iodochlorhydroxyquin) هو عامل موضعي مضاد للفطريات مع نشاط مضاد للسرطان.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 130-26-7
Sample solution is provided at 25 µL, 10mM.
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Clioquinol(Iodochlorhydroxyquin) is an antifungal drug and antiprotozoal compound that shows effectivity for Alzheimer's disease treatment and induce cancer cell death.
[1]. Nguyen T, et al. Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11840-5. [2]. Cao B, et al. Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway. Sci Rep. 2014 Jul 18;4:5749. [3]. Katsuyama M, et al. Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression. J Pharmacol Sci. 2014;124(4):427-32. [4]. Matlack KE, et al. Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4013-8.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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