Corynoxine (hydrochloride) |
رقم الكتالوجGC52477
One-Click Copy Product Info
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An indole alkaloid
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Corynoxine is an indole alkaloid that has been found in U. macrophylla and has neuroprotective activity.1,2 It increases levels of the autophagy marker LC3-II in Neuro2a and SH-SY5Y neuronal cells when used at concentrations ranging from 6.25 to 25 µM.1 Corynoxine (25 µM) increases degradation of wild-type and A53T mutant α-synuclein, a major component of Lewy bodies in the brain of Parkinson's disease patients, in PC12 cells, an effect that can be reversed by the autophagy inhibitors 3-methyladenine and chloroquine . It reduces increases in methamphetamine-induced locomotor activity in rats when administered at doses of 30 and 100 mg/kg.2
1.Chen, L.-L., Song, J.-X., Lu, J.-H., et al.Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathwayJ. Neuroimmune Pharmacol.9(3)380-387(2014) 2.Sakakibara, I., Terabayashi, S., Kubo, M., et al.Effect on locomotion of indole alkaloids from the hooks of Uncaria plantsPhytomedicine6(3)163-168(1999)
| Cas No. | SDF | ||
| Canonical SMILES | CO/C=C(C(OC)=O)\[C@@H]1[C@H](CC)CN2[C@@]([C@@]3(C(C=CC=C4)=C4NC3=O)CC2)([H])C1.Cl | ||
| Formula | C22H28N2O4 ? HCl | M.Wt | 420.9 |
| الذوبان | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.25 mg/ml,Ethanol: 3 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.3759 mL | 11.8793 mL | 23.7586 mL |
| 5 mM | 475.2 μL | 2.3759 mL | 4.7517 mL |
| 10 mM | 237.6 μL | 1.1879 mL | 2.3759 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A crystalline solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)