COX/5-LO-IN-1 (Synonyms: Atreleuton analog) |
| رقم الكتالوجGC31967 |
COX / 5-LO-IN-1 (تناظرية Atreleuton) هو مثبط لانزيم سيلوكسيجيناز و 5-ليبوكسجيناز (5-LO) ، ويستخدم في البحث عن حالات الأمراض الالتهابية والحساسية
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 154355-75-6
Sample solution is provided at 25 µL, 10mM.
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COX/5-LO-IN-1 is an inhibitor of cylooxygenase and 5-lipoxygenase, used for the research of inflammatory and allergic disease states.
COX/5-LO-IN-1 reduces the biosynthesis of leukotrienes B4, C4, D4, and E4 and cyclooxygenase products such as prostaglandins and thromboxane and are useful in the treatment of inflammatory and allergic disease states[1]. COX/5-LO-IN-1 shows inhibitory activities against 5-lipoxygenase, with IC50 of 0.2 μM in human whole blood[2].
[1]. Lipoxygenase and cyclooxygenase inhibiting compounds. US 5516789 A [2]. Brooks CD, et al. (R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor. J Med Chem. 1995 Nov 24;38(24):4768-75.
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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