RIP1 kinase inhibitor 1 |
| رقم الكتالوجGC37533 |
مثبط كيناز RIP1 1 (المركب 22) هو مثبط كيناز RIP1 قوي للغاية ومتوفر عن طريق الفم ويخترق الدماغ (pKi = 9.04)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2095515-38-9
Sample solution is provided at 25 µL, 10mM.
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RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04)[1]. pKi: 9.04 (RIP1 kinase)[1]
RIP1 kinase inhibitor 1 (compound 22) strongly suppresses necroptotic cell death and phosphorylation of MLKL(pMLKL) in human colorectal adenocarcinoma HT-29 cells (nectoptosis, IC50=2 nM; pMLKL, IC50=1.3 nM) as well as mouse L-cells NCTC 929 (nectoptosis, IC50=15 nM; pMLKL, IC50=2.7 nM)[1].
[1]. Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, OrallyAvailable, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61(6):2384-2409.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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