Cytochalasin E (Synonyms: NSC 175151) |
| رقم الكتالوجGC43359 |
Cytochalasin E ، وهو إيبوكسيد يحتوي على مستقلب فطري مشتق من الرشاشيات ، يمنع تكوين الأوعية الدموية ونمو الورم. Cytochalasin E هو عامل فعال لإزالة بلمرة الأكتين ، وهو يربط ويغطي النهاية الشائكة لخيوط الأكتين لمنع استطالة الأكتين.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 36011-19-5
Sample solution is provided at 25 µL, 10mM.
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Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation[1][2].
Cytochalasin E prominently inhibits the growth of A549 cells in a dose-dependent manner[3].Cytochalasin E could induce the up-regulation of autophagy-related protein (LC3-II) and SQSTM1/p62[3].
References:
[1]. Udagawa T, et al. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesisand tumor growth. J Pharmacol Exp Ther. 2000 Aug;294(2):421-7.
[2]. Lu QY, et al. Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenicmodel. Clin Cancer Res. 2005 Feb 15;11(4):1675-83.
[3]. Takanezawa Y, et al. Variation in the activity of distinct cytochalasins as autophagy inhibitiors in human lung A549 cells. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):641-647.
| Cas No. | 36011-19-5 | SDF | |
| المرادفات | NSC 175151 | ||
| Canonical SMILES | O=C(OC12[C@@]([C@H]3[C@](C)(O3)[C@@H](C)[C@@]1([H])[C@H](CC4=CC=CC=C4)NC2=O)([H])/C=C/C[C@]5([H])C)O/C=C/[C@](O)(C)C5=O | ||
| Formula | C28H33NO7 | M.Wt | 495.6 |
| الذوبان | DMF: 11 mg/ml,DMF:PBS (pH7.2) (1:30): 0.03 mg/ml,DMSO: 10 mg/ml,Ethanol: 2 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0178 mL | 10.0888 mL | 20.1776 mL |
| 5 mM | 403.6 μL | 2.0178 mL | 4.0355 mL |
| 10 mM | 201.8 μL | 1.0089 mL | 2.0178 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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