DB1976 hydrochloride |
| رقم الكتالوجGC39628 |
هيدروكلوريد DB1769 هو نظير سيلينوفين لـ DB270 ومثبط عامل النسخ PU.1 الفعال والقابل للنفاذ للخلايا. هيدروكلوريد DB1769 يمنع ارتباط PU.1 بقوة (IC50 من 10 نانومتر) ويثبط بشدة مركب PU.1 / DNA (مع تقارب DB1769-&Lambda ؛ B ، KD من 12 نانومتر) في المختبر. هيدروكلوريد DB1769 له تأثير محفز للاستماتة.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2369663-93-2
Sample solution is provided at 25 µL, 10mM.
DB1976 hydrochloride is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 hydrochloride potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-ΛB affinity, KD of 12 nM) in vitro. DB1976 hydrochloride has apoptosis-inducing effect[1][2][3].
[1]. Munde M, et al. Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines. Nucleic Acids Res. 2014 Jan;42(2):1379-90.
[2]. Stephens DC, et al. Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis. Nucleic Acids Res. 2016 May 19;44(9):4005-13.
[3]. Antony-DebrÉ I, et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017 Dec 1;127(12):4297-4313.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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