dBET23 |
| رقم الكتالوجGC63445 |
dBET23 هو مزيل طرد بروتاك BRD4 عالي الفعالية وانتقائي مع DC50 / 5h من ~ 50 نانومتر لبروتين BRD4BD1
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1957234-83-1
Sample solution is provided at 25 µL, 10mM.
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dBET23 is a highly effective and selective PROTAC BRD4 degrader with a DC50/5h of ~ 50 nM for BRD4BD1 protein[1].
dBET23 occupies the canonical binding sites on CRBN and BRD4BD1 for thalidomide and JQ1, respectively[1].
[1]. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018;14(7):706-714.
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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