DCLK1-IN-1 |
| رقم الكتالوجGC39486 |
DCLK1-IN-1 هو توفر حيوي انتقائي عن طريق الفم في مسبار كيميائي متوافق مع الجسم الحي لمجال doublelecortin مثل kinase 1 (DCLK1 kinase)يثبط DCLK1-IN-1 كينازات DCLK1 و DCLK2 (IC50: DCLK1 =9.5 / 57.2 نانومتر و DCLK2 =31/103 نانومتر في اختبار الربط والكيناز ، على التوالي)يُظهر DCLK1-IN-1 سمية منخفضة ، ويمكنه التحقيق في بيولوجيا DCLK1 وإثبات دوره في السرطان ، مثل سرطان الغدة البنكرياس القنوي (PDAC)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2222635-15-4
Sample solution is provided at 25 µL, 10mM.
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DCLK1-IN-1 is a selective, oral bioavailability in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1 kinase) domain. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases (IC50: DCLK1=9.5/57.2 nM and DCLK2=31/103 nM in binding and kinase assay, respectively). DCLK1-IN-1 shows low toxicity, and can investigate DCLK1 biology and establish its role in cancer, like DCLK1+ pancreatic ductal adenocarcinoma (PDAC)[1].
[1]. Ferguson FM, et al. Discovery of a selective inhibitor of doublecortin like kinase 1. Nat Chem Biol. 2020 Apr 6.
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