Diloxanide |
| رقم الكتالوجGC60778 |
Diloxanide هو عامل مضاد للبروتوزوا ويمكن استخدامه للبحث عن داء الزخار المعوي غير المصحوب بأعراض الناجم عن Entamoeba histolytica أو بعض أنواع العدوى الأولية الأخرى
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 579-38-4
Sample solution is provided at 25 µL, 10mM.
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Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate[1].
Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate[1].Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats[2].
[1]. DB08792 [2]. D K Chatterjee, et al. Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Parasitol Res. 1987;74(1):30-3.
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