Dipivefrin (hydrochloride) |
| رقم الكتالوجGC43476 |
Dipivefrin (هيدروكلوريد) (Dipivefrine hydrochloride) هو دواء أولي مضاد للزرق الذي يتحلل إلى المركب الفعال ، الإبينفرين ، بواسطة إسترات في القرنية.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 64019-93-8
Sample solution is provided at 25 µL, 10mM.
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Dipivefrin is a prodrug of epinephrine that is hydrolyzed by cholinesterase and other esterases in the cornea to epinephrine. It reduces the density of cultured bovine primary trabecular meshwork cells (IC50 = 115 µM). Additionally, it induces an elongated, fibroblast-like morphology and disrupts the actin cytoskeleton in bovine primary trabecular meshwork cells when used at a concentration of 103 µM. In cultured bovine corneal endothelial cells, dipivefrin (28 µM) enhances calcium signaling and induces cytotoxicity. Dipivefrin also suppresses primary human corneal keratinocyte proliferation when used at a concentration of 280 µM. Formulations containing dipivefrin have been used alone and in combination with β-adrenergic receptor antagonists for the treatment of glaucoma.
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