DY 268 |
| رقم الكتالوجGC46012 |
DY 268 هو أحد مضادات مستقبلات X farnesoid (FXR) (IC50 \u003d 7.5 نانومتر في اختبار FRET الذي تم حله بمرور الوقت).
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Cas No.: 1609564-75-1
Sample solution is provided at 25 µL, 10mM.
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DY 268 is a farnesoid X receptor (FXR) antagonist (IC50 = 7.5 nM in a time-resolved FRET assay).[1] It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM.
Reference:
[1]. Yu, D.D., Lin, W., Forman, B.M., et al. Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg. Med. Chem. 22(11), 2919-2938 (2014).
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