E-4031 dihydrochloride |
| رقم الكتالوجGC17661 |
KV11.1 (hERG) channels blocker
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 113559-13-0
Sample solution is provided at 25 µL, 10mM.
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E-4031 is a class III antiarrhythmic agent which selectively blocks hERG potassium channel.
References:
[1]. Nalos L, et al. Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. Br J Pharmacol. 2012 Jan;165(2):467-78.
[2]. Verheijck EE, et al. Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ Res. 1995 Apr;76(4):607-15.
[3]. Izumi-Nakaseko H, et al. Effects of selective IKr channel blockade by E-4031 on ventricular electro-mechanical relationship in the halothane-anesthetized dogs. Eur J Pharmacol. 2014 Oct 5;740:263-70.
[4]. Izumi D, et al. Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog. Pacing Clin Electrophysiol. 2010 Aug;33(8):950-9.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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