EM-12 (Synonyms: EM-12) |
رقم الكتالوجGC49522 |
يعد EM-12 (EM-12) ، وهو نظير للثاليدومايد ماسخ ، أكثر نشاطًا من الثاليدومايد وأكثر استقرارًا في حالة التحلل المائي. يعزز EM-12 تحريض 1،2-ثنائي ميثيل هيدرازين من أورام القولون الغدية في الفئران.
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Cas No.: 26581-81-7
Sample solution is provided at 25 µL, 10mM.
EM-12 is a derivative of thalidomide with teratogenic activity.1 Intravenous administration of EM-12 (150 mg/kg) to pregnant females induces fetal resorption and skeletal malformation in surviving offspring in rats, rabbits, and rhesus monkeys. Dietary administration of EM-12 (12% w/w) enhances 1,2-dimethylhydrazine-induced colonic adenocarcinoma formation in rats.2
1.Schumacher, H.J., Terapane, J., Jordan, R.L., et al.The teratogenic activity of a thalidomide analogue, EM12 in rabbits, rats, and monkeysTeratology5(2)233-240(1972) 2.Gershbein, L.L.The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomasCancer Lett.60(2)129-133(1991)
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