EM-12 (Synonyms: EM-12) |
| Katalog-Nr.GC49522 |
EM-12 (EM-12), ein teratogenes Thalidomid-Analogon, ist aktiver als Thalidomid und viel stabiler gegen Hydrolyse. EM-12 verstÄrkt die 1,2-Dimethylhydrazin-Induktion von Dickdarm-Adenokarzinomen bei Ratten.
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Cas No.: 26581-81-7
Sample solution is provided at 25 µL, 10mM.
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EM-12 is a derivative of thalidomide with teratogenic activity.1 Intravenous administration of EM-12 (150 mg/kg) to pregnant females induces fetal resorption and skeletal malformation in surviving offspring in rats, rabbits, and rhesus monkeys. Dietary administration of EM-12 (12% w/w) enhances 1,2-dimethylhydrazine-induced colonic adenocarcinoma formation in rats.2
1.Schumacher, H.J., Terapane, J., Jordan, R.L., et al.The teratogenic activity of a thalidomide analogue, EM12 in rabbits, rats, and monkeysTeratology5(2)233-240(1972) 2.Gershbein, L.L.The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomasCancer Lett.60(2)129-133(1991)
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