(-)-epigallocatechin (Synonyms: (-)EGC, epi-Gallocatechin, NSC 674039) |
رقم الكتالوجGC17242 |
(-) - Epigallocatechin (Epigallocatechin) هو أكثر الفلافونويد وفرة في الشاي الأخضر ، ويمكن أن يرتبط بالببتيدات الأصلية غير المطوية ويمنع التحول إلى ألياف أميلويد
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 970-74-1
Sample solution is provided at 25 µL, 10mM.
(-)-epigallocatechin is a polyphenol in green tea [1].
(-)-epigallocatechin (EGC) plays an important role in cell growth inhibition, apoptosis and bone metabolism.
(-)-epigallocatechin is a polyphenol in green tea. In MCF-7 and MDA-MB-231 breast cancer cell lines, EGC significantly inhibited cell growth and induced apoptosis, which were independent of p53 and required Fas signaling [1]. In H1299 cells, EGC (10-40 µM) reduced cell viability in a dose dependent way. In Hep-3B cells, EGC (40/80 µM) also reduced cell viability. However, EGC (20 µM) slightly increased cell viabilities in SK-Hep-1 and OECM-1 cells but significantly decreased cell viabilities at concentrations up to 40 µM. EGC exhibited cytotoxicity with IC50 values of 26, 33 and 22 µM in H1299, OECM-1 and SAS cells, respectively. In H1299, OECM-1 and SAS cells, EGC (40 µM) induced apoptosis by 30, 28 and 24%, respectively. In H1299 cells, EGC (40 µM) inhibited hTERT promoter activity in a time- and dose- dependent way and also inhibited hTERT mRNA expression, which was important for cell proliferation [2].
In ICR mice, EGC (0.5 and 1.0 g/kg/d) significantly inhibited platelet aggregation by 18.4% and 25.6% respectively and also significantly prolonged blood clotting time (BCT) and bleeding time (BT), which suggested that the blood anticoagulation and antiplatelet activity of EGC [3].
References:
[1]. Vergote D, Cren-Olivé C, Chopin V, et al. (-)-Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of their normal counterparts. Breast Cancer Res Treat, 2002, 76(3): 195-201.
[2]. Lin SC, Li WC, Shih JW, et al. The tea polyphenols EGCG and EGC repress mRNA expression of human telomerase reverse transcriptase (hTERT) in carcinoma cells. Cancer Lett, 2006, 236(1): 80-88.
[3]. Chen XQ, Wang XB, Guan RF, et al. Blood anticoagulation and antiplatelet activity of green tea (-)-epigallocatechin (EGC) in mice. Food Funct, 2013, 4(10): 1521-1525.
Cas No. | 970-74-1 | SDF | |
المرادفات | (-)EGC, epi-Gallocatechin, NSC 674039 | ||
Chemical Name | (2R,3R)-2-(3,4,5-trihydroxyphenyl)chroman-3,5,7-triol | ||
Canonical SMILES | O[C@@H]1CC2=C(C=C(O)C=C2O)O[C@@H]1C3=CC(O)=C(O)C(O)=C3 | ||
Formula | C15H14O7 | M.Wt | 306.27 |
الذوبان | DMF: 25 mg/ml,DMSO: 15 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 1 mg/ml | Storage | Store at -20°C,protect from light |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
1 mM | 3.2651 mL | 16.3255 mL | 32.6509 mL |
5 mM | 0.653 mL | 3.2651 mL | 6.5302 mL |
10 mM | 0.3265 mL | 1.6325 mL | 3.2651 mL |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Quality Control & SDS
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- Purity: >98.00%
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Average Rating: 5
(Based on Reviews and 8 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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