الصفحة الرئيسية>>Signaling Pathways>> Ubiquitination/ Proteasome>> Autophagy>>(-)-epigallocatechin

(-)-epigallocatechin (Synonyms: (-)EGC, epi-Gallocatechin, NSC 674039)

رقم الكتالوجGC17242

(-) - Epigallocatechin (Epigallocatechin) هو أكثر الفلافونويد وفرة في الشاي الأخضر ، ويمكن أن يرتبط بالببتيدات الأصلية غير المطوية ويمنع التحول إلى ألياف أميلويد

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(-)-epigallocatechin التركيب الكيميائي

Cas No.: 970-74-1

الحجم السعر المخزون الكميّة
1mg
19٫00
متوفر
5mg
29٫00
متوفر
10mg
50٫00
متوفر
20mg
97٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of (-)-epigallocatechin

(-)-epigallocatechin is a polyphenol in green tea [1].

(-)-epigallocatechin (EGC) plays an important role in cell growth inhibition, apoptosis and bone metabolism.

(-)-epigallocatechin is a polyphenol in green tea. In MCF-7 and MDA-MB-231 breast cancer cell lines, EGC significantly inhibited cell growth and induced apoptosis, which were independent of p53 and required Fas signaling [1]. In H1299 cells, EGC (10-40 µM) reduced cell viability in a dose dependent way. In Hep-3B cells, EGC (40/80 µM) also reduced cell viability. However, EGC (20 µM) slightly increased cell viabilities in SK-Hep-1 and OECM-1 cells but significantly decreased cell viabilities at concentrations up to 40 µM. EGC exhibited cytotoxicity with IC50 values of 26, 33 and 22 µM in H1299, OECM-1 and SAS cells, respectively. In H1299, OECM-1 and SAS cells, EGC (40 µM) induced apoptosis by 30, 28 and 24%, respectively. In H1299 cells, EGC (40 µM) inhibited hTERT promoter activity in a time- and dose- dependent way and also inhibited hTERT mRNA expression, which was important for cell proliferation [2].

In ICR mice, EGC (0.5 and 1.0 g/kg/d) significantly inhibited platelet aggregation by 18.4% and 25.6% respectively and also significantly prolonged blood clotting time (BCT) and bleeding time (BT), which suggested that the blood anticoagulation and antiplatelet activity of EGC [3].

References:
[1].  Vergote D, Cren-Olivé C, Chopin V, et al. (-)-Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of their normal counterparts. Breast Cancer Res Treat, 2002, 76(3): 195-201.
[2].  Lin SC, Li WC, Shih JW, et al. The tea polyphenols EGCG and EGC repress mRNA expression of human telomerase reverse transcriptase (hTERT) in carcinoma cells. Cancer Lett, 2006, 236(1): 80-88.
[3].  Chen XQ, Wang XB, Guan RF, et al. Blood anticoagulation and antiplatelet activity of green tea (-)-epigallocatechin (EGC) in mice. Food Funct, 2013, 4(10): 1521-1525.

Chemical Properties of (-)-epigallocatechin

Cas No. 970-74-1 SDF
المرادفات (-)EGC, epi-Gallocatechin, NSC 674039
Chemical Name (2R,3R)-2-(3,4,5-trihydroxyphenyl)chroman-3,5,7-triol
Canonical SMILES O[C@@H]1CC2=C(C=C(O)C=C2O)O[C@@H]1C3=CC(O)=C(O)C(O)=C3
Formula C15H14O7 M.Wt 306.27
الذوبان DMF: 25 mg/ml,DMSO: 15 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 1 mg/ml Storage Store at -20°C,protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (-)-epigallocatechin

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1 mg 5 mg 10 mg
1 mM 3.2651 mL 16.3255 mL 32.6509 mL
5 mM 0.653 mL 3.2651 mL 6.5302 mL
10 mM 0.3265 mL 1.6325 mL 3.2651 mL
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