Eribulin mesylate |
| رقم الكتالوجGC12483 |
مشتق اصطناعي للهاليكوندرين بي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 441045-17-6
Sample solution is provided at 25 µL, 10mM.
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Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used in the treatment of metastatic breast cancer. Eribulin mesylate (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.
References:
[1]. Okouneva, T., et al., Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase. Mol Cancer Ther, 2008. 7(7): p. 2003-11.
[2]. Smith, J.A., et al., Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability. Biochemistry, 2010. 49(6): p. 1331-7.
[3]. Towle, M.J., et al., Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res, 2011. 71(2): p. 496-505.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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