Eugenol |
| رقم الكتالوجGC16517 |
الأوجينول هو زيت أساسي موجود في القرنفل مع نشاط مضاد للبكتيريا وطارد للديدان ومضاد للأكسدة
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 97-53-0
Sample solution is provided at 25 µL, 10mM.
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Eugenol, a phenylpropanoid class compounds, is a colourless to pale yellow oily liquid extracted from certain essential oils, such as clove oil, cinnamon, nutmeg, basil and bay leaf.
In vitro: Previous study showed that eugenol could deplete intracellular GSH, inhibit GJIC and ROS generation, and had a modest effect on MMP at concentrations of 10 to 100 μM. Eugenol at high concentrations was also able to affecte [Ca2+i, PMP, as well as nd pH. The earliest and most potent effects of either was found on GSH levels and GJIC. In addition, the coadministration of glutathione ethyl ester enhanced intracellular GSH levels by almost 100% and protected cells from cell death caused by eugenol completely. Such results indicated that eugenol exhibited its hepatotoxic effects mainly via depletion of cytoprotective thiols and disruptioin in thiol-dependent processes [1].
In vivo: Animal study showed that the pretreatment with a single dose of eugenol that was 1 h before indomethacin administration was fond to cause significant reductions in gastric acid outputs, gastric mucosal lesions, as well as pepsin activity with a obvioius increase in mucin concentration. In addition, eugenol could also attenuate the elevations in gastric mucosal malondialdehyde and total nitrite significantly [2].
Clinical trial: Clinical study has been conducted to evaluate the effects of zinc oxide eugenol and metapex in root canal treatment of primary teeth. Results showed that both zinc oxide eugenol and metapex had encouraging results, however, metapex could be more safely used whenever there was a doubt about the patient's follow-up return [3].
References:
[1] Thompson DC,Barhoumi R,Burghardt RC. Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays. Toxicol Appl Pharmacol.1998 Mar;149(1):55-63.
[2] Morsy MA,Fouad AA. Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats. Phytother Res.2008 Oct;22(10):1361-6.
[3] Gupta S,Das G. Clinical and radiographic evaluation of zinc oxide eugenol and metapex in root canal treatment of primary teeth. J Indian Soc Pedod Prev Dent.2011 Jul-Sep;29(3):222-8.
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Cell experiment: |
The essential oil and eugenol are diluted in aqueous solution of Tween 20 (0.5%) in the following concentrations: 0.0625, 0.12, 0.25, 0.5 and 1.0% to be used in the egg hatch test[1]. |
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Animal experiment: |
Rats: The treatment groups of arthritic rats are given either ingwerol (0.33 mL/kg or 33 mg/kg) or eugenol (0.33 mL/kg or 33 mg/kg) orally 1 day prior to the induction of arthritis. This treatment is continued for 26 days on a daily basis. Mycobaterium trated rats receive physiological saline orally[4]. |
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References: [1]. Pessoa LM, et al. Anthelmintic activity of essential oil of Ocimum gratissimum Linn. and eugenol against Haemonchus contortus. Vet Parasitol. 2002 Oct 16;109(1-2):59-63. |
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| Cas No. | 97-53-0 | SDF | |
| Chemical Name | 4-allyl-2-methoxyphenol | ||
| Canonical SMILES | C=CCC1=CC(OC)=C(O)C=C1 | ||
| Formula | C10H12O2 | M.Wt | 164.2 |
| الذوبان | DMSO : 100mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.0901 mL | 30.4507 mL | 60.9013 mL |
| 5 mM | 1.218 mL | 6.0901 mL | 12.1803 mL |
| 10 mM | 0.609 mL | 3.0451 mL | 6.0901 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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