Fibrinopeptide B, human (FPB,human) |
| رقم الكتالوجGC31920 |
الفيبرينوببتيد B ، الإنسان (FPB ، الإنسان) عبارة عن ببتيد 14-aa ، تم إطلاقه من الطرف الأميني لـ β ؛ - سلاسل الفيبرينوجين بواسطة الثرومبين.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 36204-23-6
Sample solution is provided at 25 µL, 10mM.
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Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin.
Fibrinopeptide B, human is released from the amino-terminus of the B 3-chains of fibrinogen by thrombin. Fibrinopeptide B, human (hFpB, 10 nM) causes directed cell migration of neutrophils (PMN), and fibroblasts. Fibrinopeptide B, human also possesses potent chemotactic activity relative to human complement (C5a), leukotriene B4 (LTB4), and formyl-methionylleucyl-phenylalanine (fMLP), and for fibroblasts its chemotactic activity is comparable to that of platelet-derived growth factor. However, Fibrinopeptide B, human is not chemotactic for monocytes, and shows no interaction with PMN receptor for C5a, LTB4, or fMLP[1].
[1]. Senior RM, et al. Effects of fibrinogen derivatives upon the inflammatory response. Studies with human fibrinopeptide B. J Clin Invest. 1986 Mar;77(3):1014-9.
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