Taniborbactam hydrochloride (Synonyms: VNRX-5133 hydrochloride) |
| رقم الكتالوجGC39726 |
تانيبورباكتام هيدروكلوريد (VNRX-5133 هيدروكلوريد) هو مثبط انتقائي وقابل للانعكاس يحتوي على حمض البورونيك يحتوي على طيف كامل β-lactamase مع IC50s من 8-530 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2244235-49-0
Sample solution is provided at 25 µL, 10mM.
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Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria[1][2].
[1]. Krajnc A, et al. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. J Med Chem. 2019 Sep 26;62(18):8544-8556. [2]. Liu B ,et al. Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2019 Dec 16.
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