Fmoc-NH-PEG8-CH2COOH |
| رقم الكتالوجGC64814 |
Fmoc-NH-PEG8-CH2COOH هو رابط ADC قابل للانقسام يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs)Fmoc-NH-PEG8-CH2COOH هو أيضًا رابط PROTAC قائم على PEG ويمكن استخدامه في تركيب PROTACs
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Cas No.: 868594-52-9
Sample solution is provided at 25 µL, 10mM.
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Fmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG8-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Michael A, et al. Synthesis of Bifunctional Integrin‐Binding Peptides Containing PEG Spacers of Defined Length for Non‐Viral Gene Delivery. Volume2008, Issue17.
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