Fmoc-NH-PEG8-CH2COOH |
| Catalog No.GC64814 |
Fmoc-NH-PEG8-CH2COOH es un enlazador de ADC escindible que se utiliza en la sÍntesis de conjugados de anticuerpo y fÁrmaco (ADC). Fmoc-NH-PEG8-CH2COOH también es un enlazador PROTAC basado en PEG que se puede usar en la sÍntesis de PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 868594-52-9
Sample solution is provided at 25 µL, 10mM.
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Fmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG8-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Michael A, et al. Synthesis of Bifunctional Integrin‐Binding Peptides Containing PEG Spacers of Defined Length for Non‐Viral Gene Delivery. Volume2008, Issue17.
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