FPTQ |
| رقم الكتالوجGC30224 |
FPTQ هو مضاد mGluR1 قوي مع قيم IC لـ 6 نانومتر و 1.4 نانومتر للإنسان والفأر mGluR1 على التوالي
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Cas No.: 864863-72-9
Sample solution is provided at 25 µL, 10mM.
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FPTQ is mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. Inhibit [3H] FTIDC target: mGluR1IC 50: 6 nM [1]In vivo: FPTQ exhibited dose-dependent and plasma concentration-dependent receptor occupancy in the cerebellum and striatum. Compound A inhibit (S)-3,5-DHPG-induced face-washing behavior by 46 ± 14% and 97 ± 6.6% (mean ± S.E.M., n = 6) at 10 and 30 mg/kg, respectively.[2]
[1]. Fujinaga M et al. Synthesis and evaluation of 6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain. Bioorg Med Chem, 2011 Jan 1, 19(1):102 [2]. Suzuki G et al. Correlation of receptor occupancy of metabotropic glutamate receptor subtype 1 (mGluR1) in mouse brain with in vivo activity of allosteric mGluR1 antagonists. J Pharmacol Sci, 2009 Jul, 110(3):315-25.
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