Cyclo(-D-Leu-D-Pro) |
رقم الكتالوجGA21315
One-Click Copy Product Info
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Cyclo(-D-Leu-D-Pro) is a cyclic dipeptide from Pseudonocardia endophytica VUK-10, with antifungal activities.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 274680-11-4
Sample solution is provided at 25 µL, 10mM.
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Cyclo(-D-Leu-D-Pro) is a cyclic dipeptide from Pseudonocardia endophytica VUK-10, with antifungal activities [1]. Cyclo(-D-Leu-D-Pro) has significantly inhibitory activity against conidial germination of C. orbiculare and can reduce lesion occurrence [2]. Cyclo(-D-Leu-D-Pro) significantly inhibits the growth of A. parasiticus and reduced the production of aflatoxins[3]. Cyclo(-D-Leu-D-Pro) has been widely used as an internal reference to optimize the parameters of high-resolution gas chromatography-mass spectrometry (HRGC/MS) detection methods for quantifying cyclic dipeptides in lactic acid bacteria cultures[4].
References:
[1] Bailly C. Insights into the Bioactivities and Mechanism of Action of the Microbial Diketopiperazine Cyclic Dipeptide Cyclo (L-leucyl-L-prolyl)[J]. Marine Drugs, 2025, 23(10): 397.
[2] Kim J, Kim J C, Sang M K. Identification of isomeric cyclo (leu-pro) produced by Pseudomonas sesami BC42 and its differential antifungal activities against Colletotrichum orbiculare[J]. Frontiers in Microbiology, 2023, 14: 1230345.
[3] Yan P S, Song Y, Sakuno E, et al. Cyclo (L-leucyl-L-prolyl) produced by Achromobacter xylosoxidans inhibits aflatoxin production by Aspergillus parasiticus[J]. Applied and environmental microbiology, 2004, 70(12): 7466-7473.
[4] Axel C, Zannini E, Arendt E K, et al. Quantification of cyclic dipeptides from cultures of Lactobacillus brevis R2Δ by HRGC/MS using stable isotope dilution assay[J]. Analytical and bioanalytical chemistry, 2014, 406(9): 2433-2444.
| Cas No. | 274680-11-4 | SDF | |
| Formula | C11H18N2O2 | M.Wt | 210.28 |
| الذوبان | DMSO : 125 mg/mL (594.47 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.7556 mL | 23.7778 mL | 47.5556 mL |
| 5 mM | 951.1 μL | 4.7556 mL | 9.5111 mL |
| 10 mM | 475.6 μL | 2.3778 mL | 4.7556 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)