GAK inhibitor 49 |
| رقم الكتالوجGC60863 |
مثبط GAK 49 هو مثبط كيناز (GAK) قوي ، منافس لـ ATP وانتقائي للغاية مع Ki 0.54 نانومتر وخلية IC 50 من 56 نانومتر
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Cas No.: 319492-82-5
Sample solution is provided at 25 µL, 10mM.
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GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 also shows binding to RIPK2[1].
GAK inhibitor 49 (compound 49) shows a weak inhibitory effect on AAK1, BMP2K and STK16, with IC50s of 28, 63 and >100μM, respectively[1].
[1]. Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018;13(1):48-66.
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