Abemaciclib Metabolites M2 (Synonyms: LSN2839567) |
| رقم الكتالوجGC35218 |
Abemaciclib Metabolites M2 (LSN2839567) هو مستقلب من Abemaciclib ، يعمل كمثبط قوي لـ CDK4 و CDK6 ، مع IC50s 1.2 و 1.3 نانومتر ، على التوالي. نشاط مضاد للسرطان.
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Cas No.: 1231930-57-6
Sample solution is provided at 25 µL, 10mM.
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Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1]. CDK4|1-3 nM (IC50)|CDK6|1-3 nM (IC50)
[1]. Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).
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