AVX 13616 |
| رقم الكتالوجGC35439 |
يُظهر AVX 13616 النشاط المضاد للبكتيريا الفعال في الجسم الحي لمرشح مضاد للجراثيم من Avexa ؛ خاصة ضد مسببات الأمراض المقاومة للأدوية
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 900814-48-4
Sample solution is provided at 25 µL, 10mM.
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AVX 13616 shows the potent in vivo antibacterial activity of Avexa's lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens.IC50 value: 2-4 ug/ml (MICs)Target: antibacterial agent AVX13616 was as active as mupirocin in a nasal decolonization model but required only a single application. The compounds are being developed for topical indications and/or wound infection/catheter-related infections. AVX13616 and other compounds showed broad spectrum antibacterial activity against a range of isolates with MICs of 2-4 micrograms per millilitre against S. aureus, coagulase negative staphylococci, enterococci, MRSA, VISA and VRSA. A single application of 5% (w/w) AVX13616 (approximately equimolar to 2% mupirocin) was as effective as 2% mupirocin administered twice a day for five days in nasal decolonisation of MRSA in mice.
[1]. Avexa Presents Data from Apricitabine and Antibacterial Programs at two International Conferences
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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