HIV-1 integrase inhibitor 4 |
| رقم الكتالوجGC36235 |
مثبط HIV-1 Integrase 4 هو مثبط لنقل حبلا HIV-1 Integrase (INST) مع IC50 يبلغ 3.7 نانومتر
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Cas No.: 1638504-66-1
Sample solution is provided at 25 µL, 10mM.
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HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM. IC50: 3.7 nM (INST)[1]
HIV-1 integrase inhibitor 4 (compound 4f) is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM. HIV-1 integrase inhibitor 4 shows potent activity against recombinant HIV IN in biochemical assays and good efficacy in assays done in cell culture against a broad panel of viral mutants carrying the major RAL and DTG IN resistance mutations[1].
[1]. Zhao XZ, et al. HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant MutantIntegrases. ACS Chem Biol. 2016 Apr 15;11(4):1074-81.
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