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DMT1 blocker 2

رقم الكتالوجGC35886

يعتبر مانع DMT1 2 مثبطًا مباشرًا لناقل المعادن ثنائي التكافؤ 1 (DMT1) ، مع IC50 بمقدار 0.83 ميكرومتر

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DMT1 blocker 2 التركيب الكيميائي

Cas No.: 1062648-63-8

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
248٫00
متوفر
5mg
225٫00
متوفر
10mg
405٫00
متوفر
10mg
405٫00
متوفر
25mg
765٫00
متوفر
50mg
1215٫00
متوفر
100mg
1755٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


مراجعات العميل

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  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

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Sample solution is provided at 25 µL, 10mM.

Description of DMT1 blocker 2

DMT1 blocker 2, Compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 of 0.83 μM, is expected to block iron uptake by enterocytes in vivo[1].

IC50: 0.83 μM (DMT1 blocker 2)[1]

[1]. Cadieux JA, et al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett. 2012 Jan 1;22(1):90-5.

Chemical Properties of DMT1 blocker 2

Cas No. 1062648-63-8 SDF
Canonical SMILES OC1=C2C3=C(C=CC=C3)CCC2=NN1C4=NC=CC=C4
Formula C16H13N3O M.Wt 263.29
الذوبان DMSO : 50 mg/mL (189.90 mM; Need ultrasonic) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of DMT1 blocker 2

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.7981 mL 18.9905 mL 37.9809 mL
5 mM 0.7596 mL 3.7981 mL 7.5962 mL
10 mM 0.3798 mL 1.899 mL 3.7981 mL
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In vivo Formulation Calculator (Clear solution) of DMT1 blocker 2

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 32 reference(s) in Google Scholar.)

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