IDO/TDO-IN-1 |
رقم الكتالوجGC36294 |
IDO / TDO-IN-1 (المركب 25) هو مثبط ثنائي الإندوليمين -2 ، 3-ديوكسيجيناز (IDO) قوي للغاية ونشط عن طريق الفم ومثبط التربتوفان 2،3-ديوكسيجيناز (TDO) مع IC50s من 9.7 و 47 نانومتر ، على التوالي
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Cas No.: 2033173-01-0
Sample solution is provided at 25 µL, 10mM.
IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1]. IC50: 9.7 nM (Indoleamine-2,3-dioxygenase), 47 nM (Tryptophan 2,3-dioxygenase)[1]
IDO/TDO-IN-1 inhibits IDO in the Hela cell line with an IC50 of 76 nM[1].
[1]. Tu W, et al. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953.
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