J30-8 |
| رقم الكتالوجGC36359 |
J30-8 هو مثبط قوي وانتقائي للشكل الإسوي لـ c-Jun N-terminal kinase 3 (JNK3) مع IC50 من 40 نانومتر ، والذي يتميز بانتقائية 2500 ضعف مقابل JNK1α1 و JNK2α2
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2366255-71-0
Sample solution is provided at 25 µL, 10mM.
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J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases[1]. JNK3|40 nM (IC50)
[1]. Dou X, et al. Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases. J Med Chem. 2019 Jul 25;62(14):6645-6664.
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