J30-8 |
カタログ番号GC36359 |
J30-8 は、c-Jun N 末端キナーゼ 3 (JNK3) の強力なアイソフォーム選択的阻害剤であり、IC50 は 40 nM であり、JNK1α1 および JNK2α2 に対して 2500 倍のアイソフォーム選択性があります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2366255-71-0
Sample solution is provided at 25 µL, 10mM.
J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases[1]. JNK3|40 nM (IC50)
[1]. Dou X, et al. Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases. J Med Chem. 2019 Jul 25;62(14):6645-6664.
Average Rating: 5
(Based on Reviews and 10 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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