ML367 |
| رقم الكتالوجGC36630 |
ML367 هو مثبط قوي لاستقرار البروتين 5 (ATAD5) المحتوي على مجال ATPase من عائلة ATPase ، ويعمل كجزيء مسبار له نشاط مثبط منخفض للميكرومولاريحجب ML367 مسارات إصلاح الحمض النووي ، ويقمع الاستجابات العامة لتلف الحمض النووي بما في ذلك الفسفرة RPA32 و CHK1- الفسفرة استجابة للإشعاع فوق البنفسجي
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Cas No.: 381168-77-0
Sample solution is provided at 25 µL, 10mM.
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ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1]. ATAD5[1]
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd[1]. Western Blot Analysis[1] Cell Line: HEK293T cells
[1]. Rohde JM, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program.
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