Sodium Channel inhibitor 1 |
| رقم الكتالوجGC37659 |
مثبط قناة الصوديوم 1 ، واحد من 3-Oxoisoindoline-1-carboxamides ، عبارة عن قناة صوديوم جديدة وانتقائية ذات جهد كهربائي لعلاج الألم
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1198117-23-5
Sample solution is provided at 25 µL, 10mM.
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Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment. IC50 Value: 0.16 uM ( Na v1.7, V hold-90mV); 0.41 uM (Na v1.7, V hold-90mV) [1]Target: Na v1.7Sodium Channel inhibitor1 demonstrated concentration-dependent efficacy in preclinical behavioral pain models.
[1]. Macsari I, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55(15):6866-80.
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