Taccalonolide B |
| رقم الكتالوجGC37717 |
Taccalonolide B هو مثبت للأنابيب الدقيقة معزول من Tacca plantaginea ، مع نشاط مضاد للأورامTaccalonolide B فعال في المختبر ضد خطوط الخلايا التي تزيد من إفراز البروتين P-glycoprotein (Pgp) والبروتين المقاوم للأدوية المتعددة (MRP7)يمنع Taccalonolide B نمو خلايا SK-OV-3 مع IC50 من 208 نانومتر
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Cas No.: 108885-69-4
Sample solution is provided at 25 µL, 10mM.
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Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM[1][2]. microtubule[2]
[1]. LiangChen Zhong, et al. Steroidal bitter principles from tacca plantaginea structures of taccalonolide A and B. Tetrahedron Letters. 1987, 28(15): 1673-1675. [2]. Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8.
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