Tyk2-IN-7 |
| رقم الكتالوجGC37846 |
Tyk2-IN-7 (المركب 48) هو مثبط TYK2 JH2 ، يرتبط بنطاق TYK2 JH2 مع IC50 و Ki
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Cas No.: 1609391-90-3
Sample solution is provided at 25 µL, 10mM.
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Tyk2-IN-7 (Compound 48) is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 (Compound 48) provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 (Compound 48) provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1]. Tyk2 JH2|0.00053 μM (IC50)|Tyk2 JH2|0.00007 μM (Ki app)
[1]. Moslin R, et al. Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2). J Med Chem. 2019 Jul 17.
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