VU 6008667 |
| رقم الكتالوجGC37928 |
VU 6008667 عبارة عن مُعدِّل خيفي انتقائي سلبي لـ M5 NAM مع IC50s 1.2 ميكرومتر و 1.6 ميكرومتر للإنسان M5 والفأر M5 ، على التوالي
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Cas No.: 2092923-21-0
Sample solution is provided at 25 µL, 10mM.
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VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. VU 6008667 has high CNS penetration[1].
[1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.
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