Stigmastanol |
رقم الكتالوجGD21338
One-Click Copy Product Info
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Stigmastanol is a saturated form of natural phytosterols, belonging to the phytosterol class of compounds, with a chemical structure similar to cholesterol.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 19466-47-8
Sample solution is provided at 25 µL, 10mM.
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Stigmastanol is a saturated form of natural phytosterols, belonging to the phytosterol class of compounds, with a chemical structure similar to cholesterol [1]. Stigmastanol can lower blood lipids by inhibiting cholesterol absorption [2]. Stigmastanol is often used in functional foods for preventing and treating hypercholesterolemia [3].
In PC12 cells, Stigmastanol (1µM, 2µM, 3µM, 4µM, 5µM, 10µM; 24h) inhibited D-gal-induced cell apoptosis [4].
In sprague-dawley rat models, Stigmastanol (50mg/kg; po; single administered) significantly inhibited intestinal cholesterol absorption after oral administration [5].
References:
[1]. Pinhas H, Loiseau A, Krikorian-Manoukian A, et al. 6-Amino derivatives of stigmastanol and cholestanol. Journal of Medicinal Chemistry. 1971 Nov; 14(11): 1048-1049.
[2]. Vahouny GV, Connor WE, Habiger RG, et al. Influence of stigmastanol and stigmastanyl-phosphorylcholine, two plasma cholesterol lowering substances, on synthetic phospholipid membranes. A 2H-and 31P-NMR study. Biochimica et Biophysica Acta (BBA)-Biomembranes. 1992 Jan 10; 1103(1): 69-76.
[3]. Gupta E. β-Sitosterol: Predominant phytosterol of therapeutic potential. Innovations in food technology: current perspectives and future goals. 2020:465-477.
[4]. Zhang Y, Xu D, Zhang X, et al. Rice bran oil rescues cognitive decline in D-galactose-induced aging mice by inhibiting Aβ accumulation and Tau hyperphosphorylation induced oxidative stress and neuroinflammation. Food Science and Human Wellness. 2025 Jul 1; 14(7).
[5]. Gershkovich P, Darlington J, Sivak O, et al. Inhibition of intestinal absorption of cholesterol by surface-modified nanostructured aluminosilicate compounds. Journal of pharmaceutical sciences. 2009 Jul 1; 98(7): 2390-2400.
| Cell experiment [1]: | |
Cell lines | PC12 cells |
Preparation Method | The PC12 cells were seeded into a 96-well plate (1 × 105 cells/well). After 6h of incubation, the cells were treated with different concentrations of D-gal, α-linolenic acid, Stigmastanol, D-gal/α-linolenic acid, and D-gal/Stigmastanol for 24h. Cell viability for each group was assessed using the MTT assay. |
Reaction Conditions | 1µM, 2µM, 3µM, 4µM, 5µM, 10µM; 24h |
Applications | Stigmastanol inhibited D-gal-induced PC12 cells apoptosis. |
| Animal experiment [2]: | |
Animal models | Sprague-Dawley rat models |
Preparation Method | The solid food was withheld but a free access to oral liquid cholesterol-free diet consisting of 5% glucose in lactated Ringer’s was allowed following the surgery and throughout the experiment. Twenty-four hours postsurgery, animals were divided into the following 10 treatment groups: nonpurified nanostructured aluminosilicate (NSAS) 50mg/kg; sodium NSAS 50mg/kg; protonated (by ion-exchange column) NSAS 20, 50, and 100mg/kg; hydrochloric acid-treated NSAS 50mg/kg; back-converted to sodium form (by NaOH) NSAS 50mg/kg; Stigmastanol 50mg/kg; ezetimibe 10mg/kg; and normal saline (control). All compounds were administered by oral gavage. |
Dosage form | 50mg/kg; po; single administered |
Applications | Stigmastanol significantly inhibited intestinal cholesterol absorption after oral administration. |
References: | |
| Cas No. | 19466-47-8 | SDF | |
| Formula | C29H52O | M.Wt | 416.72 |
| الذوبان | Storage | Store at 2-8°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.3997 mL | 11.9985 mL | 23.9969 mL |
| 5 mM | 479.9 μL | 2.3997 mL | 4.7994 mL |
| 10 mM | 240 μL | 1.1998 mL | 2.3997 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)