Zeatin |
رقم الكتالوجGD23761
One-Click Copy Product Info
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Zeatin is a naturally occurring cytokinin-like plant hormone.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 13114-27-7
Sample solution is provided at 25 µL, 10mM.
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Zeatin is a naturally occurring cytokinin-like plant hormone [1]. Zeatin binds to cytokinin receptors, activating downstream signaling pathways, promoting cell division, differentiation, and chloroplast development, and delaying leaf senescence [2-3]. Zeatin is commonly used in anti-aging and cell regulation [4].
In tobacco, Zeatin (10μM; 24h) inhibits symptom development of Pst infection [5].
In red blood cells, Zeatin (40-200μM; 24h) causes significant hemolysis and leakage of K+, Na+, AST, and LDH [6]. In human dermal fibroblasts, Zeatin (1-200μM; 48h) treatment prevented cell enlargement, reduced intracellular debris, prevented actin polymerization, and enhanced the cells ability to break down hydrogen peroxide and respond to ethanol and oxidative stress [7].
In male ICR mice, Zeatin (1.5-4.5mg/kg; po; 4 weeks) treatment significantly improved scopolamine-induced amnesia [8]. In rat depression model, Zeatin (10mg/kg; ip; single injection) treatment produced antidepressant-like effects [9].
References:
[1]. Jameson P E. Zeatin: The 60th anniversary of its identification[J]. Plant Physiology, 2023, 192(1): 34-55.
[2]. Schäfer M, Brütting C, Meza-Canales I D, et al. The role of cis-zeatin-type cytokinins in plant growth regulation and mediating responses to environmental interactions[J]. Journal of experimental botany, 2015, 66(16): 4873-4884.
[3]. Wu W, Du K, Kang X, et al. The diverse roles of cytokinins in regulating leaf development[J]. Horticulture Research, 2021, 8.
[4]. Kesharwani A, Panda S P. Isolation of Phytohormone trans-Zeatin: Potential Oxidant Scavenger and Anti-Aging Compound[J]. Neurochemical Journal, 2024, 18(1): 134-146.
[5]. Großkinsky D, Edelsbrunner K, Pfeifhofer H, et al. Cis-and trans-zeatin differentially modulate plant immunity[J]. Plant signaling & behavior, 2013, 8(7): e24798.
[6]. Alajeyan I A, Alsughayyir J, Alfhili M A. Zeatin Elicits Premature Erythrocyte Senescence Through Calcium and Oxidative Stress Mediated by the NOS/PKC/CK1α Signaling Axis[J]. Dose-Response, 2025, 23(1): 15593258251314825.
[7]. Rattan S I S, Sodagam L. Gerontomodulatory and youth-preserving effects of zeatin on human skin fibroblasts undergoing aging in vitro[J]. Rejuvenation research, 2005, 8(1): 46-57.
[8]. Choi S J, Jeong C H, Choi S G, et al. Zeatin prevents amyloid β-induced neurotoxicity and scopolamine-induced cognitive deficits[J]. Journal of medicinal food, 2009, 12(2): 271-277.
[9]. Oz P, Timuçin A C, Teomete Ş, et al. The sex-dependent anti-depressant-like effects of zeatin in rat behavioral despair model as a candidate A2A receptor ligand[J]. Neuroscience Letters, 2020, 734: 135108.
| Plant experiment [1]: | |
Preparation Method | To address the effects of zeatin on plant immunity, an experimental design using zeatin in the tobacco-Pst pathosystem was employed. Four detached leaves from 7–10-week-old tobacco SR1 plants grown under greenhouse conditions were fed through the petiole with 10μM zeatin diluted from a 100mM stock solution in 0.5M NaOH; correspondingly diluted NaOH solutions served as solvent controls 24 hours before Pst infection. |
Reaction Conditions | 10μM; 24h |
Applications | Zeatin inhibits symptom development of Pst infection in tobacco. |
| Cell experiment [2]: | |
Cell lines | Red blood cells |
Preparation Method | Zeatin (40-200μM) was dissolved in DMSO and added to a healthy donor red blood cell suspension. The cells were incubated at 37℃ for 24h in different Ringer buffers. Hemolysis was then measured (absorbance at 405nm, with ddH2O as 100% control), and hemolysis markers such as AST, LDH, K+, and Na+ were measured using a clinical biochemistry analyzer. |
Reaction Conditions | 40-200μM; 24h |
Applications | Zeatin causes significant hemolysis and leakage of K+, Na+, AST, and LDH. |
| Animal experiment [3]: | |
Animal models | Male ICR mice |
Preparation Method | Male ICR mice, weighing 25–30g, were used for passive avoidance testing following a 1-week adaptation period (20–23℃; 12-hour light cycle from 09:00 to 21:00; food and water ad libitum). Mice were allowed free access to normal feed or feed mixed with zeatin for 4 weeks. Amnesia was induced in mice with scopolamine (1mg/kg of body weight) given subcutaneously. Behavioral tests were started 30 minutes after injection. |
Dosage form | 1.5-4.5mg/kg; po; 4 weeks |
Applications | Zeatin treatment significantly improved scopolamine-induced amnesia. |
References: | |
| Cas No. | 13114-27-7 | SDF | |
| Formula | C10H13N5O | M.Wt | 219.24 |
| الذوبان | Storage | -20°C away from moisture | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.5612 mL | 22.8061 mL | 45.6121 mL |
| 5 mM | 912.2 μL | 4.5612 mL | 9.1224 mL |
| 10 mM | 456.1 μL | 2.2806 mL | 4.5612 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)