Gitoxin |
| رقم الكتالوجGC64887 |
Gitoxin ، وهو مثبط Na + / K +- ، يظهر عادةً نتيجة للتدهور الأيضي للديجيتوكسين ، وهو مجرد مجموعة الهيدروكسيل (ZOH) القريبة من موضع C-17β ، والتي تغير الحرائك الدوائية والديناميكا الدوائية من هذه المواد إلى حد كبير
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Cas No.: 4562-36-1
Sample solution is provided at 25 µL, 10mM.
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Gitoxin, a Na+/K+-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably[1].
[1]. Danijela Krstic, et al. Effects of digoxin and gitoxin on the enzymatic activity and kinetic parameters of Na+/K+-ATPase. J Enzyme Inhib Med Chem. 2004 Oct;19(5):409-15.
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