CH7057288 |
| رقم الكتالوجGC33112 |
CH7057288 هو مثبط TRK فعال وانتقائي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2095616-82-1
Sample solution is provided at 25 µL, 10mM.
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CH7057288 is a potent and selective TRK inhibitor.
CH7057288 induces regression of intracranial tumors and greatly improves event-free survival in an intracranial implantation model mimicking brain metastasis. CH7057288 can be a promising therapeutic agent for TRK fusion-positive cancer. TRK receptor tyrosine kinases are expressed as fusion proteins encoded by various fusion genes across a wide variety of cancer types, including lung and colorectal cancer[1].
[1]. Hiroshi Tanaka, et al. Abstract 4179: Potent and selective TRK inhibitor CH7057288. AACR Annual Meeting 2017; April 1-5, 2017.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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