5'-Biotin-G-Monophosphate |
رقم الكتالوجGN20145
One-Click Copy Product Info
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5-Biotin-G-Monophosphate allows the incorporation of biotin at the 5' end of RNA and is particularly useful for the development of aptamers.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2101200-52-4
Sample solution is provided at 25 µL, 10mM.
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5-Biotin-G-Monophosphate allows the incorporation of biotin at the 5' end of RNA and is particularly useful for the development of aptamers[1]. RNA aptamers with 5'-end biotinylation can be generated by in vitro 2'-F RNA transcription using 3mM 5-Biotin-G-Monophosphate[1]. 5-Biotin-G-Monophosphate is a modified nucleotide that incorporates biotin and is a versatile and reliable labeling reagent for the detection of nucleic acids, particularly in DNA amplification, sequencing, and hybridization applications[2]. 5-Biotin-G-Monophosphate is also an ideal tool for screening and analyzing enzyme activities that depend on nucleotide substrates[3].
References:
[1] Kahsai A W, Wisler J W, Lee J, et al. Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor[J]. Nature chemical biology, 2016, 12(9): 709-716.
[2] Di Vito A, Reitano E, Poggi L, et al. Biotin oligonucleotide labeling reactions: A method to assess their effectiveness and reproducibility[J]. Analytical biochemistry, 2020, 593: 113590.
[3] Esposito C L, Autiero I, Sandomenico A, et al. Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation[J]. Nature Communications, 2023, 14(1): 99.
| purity | >95.00% | Extinction Coefficient | 13,700 Lmol-1cm-1 at 253 nm |
| Formula | C26H41N8O10PS (free acid) | M.Wt | 688.70 g/mole (free acid) |
| Salt Form | Li+ | تركيز | 100 mM |
| Buffer | H2O | Storage | -20°C or below |
| المرادفات | 5'-Biotin-GMP | Backbone | 5'-Biotin-Monophosphate |
| Base Analog | Guanosine | Sugar Type | RNA |
| Nucleotide Category | Biotin Labeled |
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)