GNE-1858 |
| رقم الكتالوجGC39631 |
GNE-1858 هو مثبط كيناز 1 (HPK1) فعال ومنافس لـ ATP ، مع IC50s من 1.9 نانومتر ، 1.9 نانومتر ، و 4.5 نانومتر للنوع البري والطفرات المحاكية النشطة HPK1-TSEE و HPK1-SA ، على التوالي
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Cas No.: 2680616-96-8
Sample solution is provided at 25 µL, 10mM.
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GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively[1].
[1]. Wu P, et al. Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure. 2019 Jan 2;27(1):125-133.e4.
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