GNE-1858 |
| Catalog No.GC39631 |
GNE-1858 est un inhibiteur puissant et compétitif de la kinase progénitrice hématopoÏétique 1 (HPK1), avec des IC50 de 1,9 nM, 1,9 nM et 4,5 nM pour le type sauvage et les mutants mimétiques actifs HPK1-TSEE et HPK1-SA, respectivement .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2680616-96-8
Sample solution is provided at 25 µL, 10mM.
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GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively[1].
[1]. Wu P, et al. Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure. 2019 Jan 2;27(1):125-133.e4.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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