GOT1 inhibitor-1 |
| رقم الكتالوجGC60884 |
مثبط GOT1-1 (المركب 2 ج) ، مشتق قائم على التربتامين ، يعمل كمثبط جديد وقوي وغير تساهمي للغلوتامات أوكسالو أسيتات ترانساميناز 1 (GOT1) مع IC50 من 8.2 ميكرومتريمكن استخدام مثبط GOT1-1 للبحث عن سرطان الغدة البنكرياس القنوي (PDAC)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 732973-87-4
Sample solution is provided at 25 µL, 10mM.
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GOT1 inhibitor-1 is a small-molecule selective inhibitor of GOT1 (glutamic oxaloacetic transaminase 1) with an IC50 of 8.2 μM. GOT1 inhibitor-1 has potential application value in cancer therapy[1]. GOT1 is a key protein in energy metabolism and the balance of reactive oxygen species (ROS)[2]. GOT1 inhibitor-1, which is N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide, can reduce the viability of cancer cells by inhibiting the activity of GOT1 and disrupting the metabolic pathway balance[1].
References:
[1] Anglin J, Zavareh RB, Sander PN, et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678.
[2] Peng H, Dou H, He S, et al. The role of GOT1 in cancer metabolism. Front Oncol. 2024 Dec 24;14:1519046.
| Cas No. | 732973-87-4 | SDF | |
| Canonical SMILES | O=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=C(Cl)C=C4 | ||
| Formula | C19H19ClN4O | M.Wt | 354.83 |
| الذوبان | DMSO: 125 mg/mL (352.28 mM); Water: < 0.1 mg/mL (insoluble) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.8183 mL | 14.0913 mL | 28.1825 mL |
| 5 mM | 563.7 μL | 2.8183 mL | 5.6365 mL |
| 10 mM | 281.8 μL | 1.4091 mL | 2.8183 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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