GSK2798745 |
| رقم الكتالوجGC39387 |
جي إس كي 2798745 هو مثبط قناة الأيونات المؤقتة لمستقبل فانيلويد الإنتقالية الفعال عن طريق الفم وذو اختيارية عالية وفعالية قوية، يصل تركيزه التثبيطى (IC50) إلى 1.8 نانومول/لتر و 1.6 نانومول/لتر لـ hTRPV4 و rTRPV4 على الترتيب.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1419609-94-1
Sample solution is provided at 25 µL, 10mM.
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GSK2798745 is a first-in-class, highly potent, selective, orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC50s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 is used in research for the treatment of pulmonary edema associated with congestive heart failure[1][2].
[1]. Goyal N, et al. Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects. Am J Cardiovasc Drugs. 2019 Jun;19(3):335-342. [2]. Brooks CA, et al. Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4). ACS Med Chem Lett. 2019 Jul 15;10(8):1228-1233.
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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