H2S Donor 5a (Synonyms: N-(Benzoylthio)benzamide) |
| رقم الكتالوجGC41630 |
مانح H2S (هيدروجين سلفيد) 5a، كمانح مستقر للهيدروجين السلفيد، يمكنه التفاعل مع وكلاء الاختزال التي تحتوي على مجموعات الثايول مثل السيستئين والجلوتاثيون المخفض لإطلاق H2S.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 134861-13-5
Sample solution is provided at 25 µL, 10mM.
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H2S (Hydrogen sulfide) Donor 5a, as a stable, cysteine activated hydrogen sulfide donor, can react with reducing agents containing sulfhydryl groups such as cysteine and reduced glutathione to release H2S. H2S Donor 5a is very stable in aqueous solution, however, it will degrade and release H2S in biological samples containing thiols such as blood, tissues or cells.[1]
H2S exerts cytoprotective and anticancer effects, promotes wound healing, inhibits platelet aggregation and protects against myocardial ischemia, etc.[2]
In vitro experiment it shown that 0.5 mg/mL and 2 mg/mL of the most promising material (5A@Chi) was loaded with H2S and added to the HeLa cells. Both concentrations, which correspond to a H2S release of 0.49 μM and 2.20 μM, respectively, indicated no toxicity after 48 h to the cells.[3]
References:
[1]Zhao Y, et al. Cysteine-activated hydrogen sulfide (H2S) donors. J Am Chem Soc. 2011 Jan 12;133(1):15-7.
[2]Zheng Y., et al. Toward hydrogen sulfide based therapeutics: Critical drug delivery and developability issues. Med. Res. Rev. 2018;38:57–100.
[3]Batista M, et al. Chitosan Biocomposites for the Adsorption and Release of H2S. Materials (Basel). 2021 Nov 7;14(21):6701.
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